Home

USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
Search by   *
 
 
 
 
 
 
Maps   
 
 


     Select Remote Interfaces
[All Interfaces]
SWISS-2DPAGE
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     
Searching in 'USC-OGP 2-DE database' for entry matching: P12814




USC-OGP 2-DE database:  P12814


P12814


General information about the entry
View entry in simple text format
Entry nameAAC1_HUMAN
Primary accession numberP12814
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Alpha-actinin-1; AltName: Full=Alpha-actinin cytoskeletal isoform; AltName: Full=F-actin cross-linking protein; AltName: Full=Non-muscle alpha-actinin-1;.
Gene nameName=ACTN1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=5.01; Mw=59800
pI=4.86; Mw=49615
pI=5.00; Mw=34710
pI=4.61; Mw=27318



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.41; Mw=119336



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.44; Mw=126814

Cross-references
UniProtKB/Swiss-ProtP12814; ACTN1_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameACTN1_HUMAN
Primary accession numberP12814
Secondary accession number(s) B3V8S3 B4DHH3 B7TY16 Q1HE25 Q9BTN1
Sequence was last modified on April 13, 2004 (version 2)
Annotations were last modified on March 15, 2017 (version 207)
Name and origin of the protein
DescriptionRecName: Full=Alpha-actinin-1; AltName: Full=Alpha-actinin cytoskeletal isoform; AltName: Full=F-actin cross-linking protein; AltName: Full=Non-muscle alpha-actinin-1;
Gene nameName=ACTN1
Encoded onName=ACTN1
Keywords3D-structure; Acetylation; Actin-binding; Alternative splicing; Calcium; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX15804; CAA33803.1; -; mRNA
EMBLM95178; AAA51582.1; -; mRNA
EMBLEU716325; ACE62922.1; -; mRNA
EMBLDQ496098; ABF50047.1; -; mRNA
EMBLFJ410030; ACJ24535.1; -; mRNA
EMBLBT007207; AAP35871.1; -; mRNA
EMBLAK295099; BAG58135.1; -; mRNA
EMBLAL117694; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471061; EAW80975.1; -; Genomic_DNA
EMBLBC003576; AAH03576.1; -; mRNA
EMBLBC015766; AAH15766.1; -; mRNA
EMBLX55187; CAA38970.1; -; mRNA
CCDSCCDS45129.1; -. [P12814-2]; .
CCDSCCDS45130.1; -. [P12814-3]; .
CCDSCCDS9792.1; -. [P12814-1]; .
PIRS05503; FAHUAA; .
RefSeqNP_001093.1; NM_001102.3. [P12814-1]; .
RefSeqNP_001123476.1; NM_001130004.1. [P12814-3]; .
RefSeqNP_001123477.1; NM_001130005.1. [P12814-2]; .
UniGeneHs.235750; -; .
UniGeneHs.509765; -; .
PDB2EYI; X-ray; 1.70 A; A=30-253
PDB2EYN; X-ray; 1.80 A; A=30-253
PDB2N8Y; NMR; -; A=743-892
PDB2N8Z; NMR; -; A=743-892
PDBsum2EYI; -; .
PDBsum2EYN; -; .
PDBsum2N8Y; -; .
PDBsum2N8Z; -; .
ProteinModelPortalP12814; -; .
SMRP12814; -; .
BioGrid106602; 126; .
DIPDIP-33184N; -; .
IntActP12814; 82; .
MINTMINT-215335; -; .
STRING9606.ENSP00000377941; -; .
iPTMnetP12814; -; .
PhosphoSitePlusP12814; -; .
SwissPalmP12814; -; .
BioMutaACTN1; -; .
DMDM46397817; -; .
OGPP12814; -; .
EPDP12814; -; .
MaxQBP12814; -; .
PaxDbP12814; -; .
PeptideAtlasP12814; -; .
PRIDEP12814; -; .
DNASU87; -; .
EnsemblENST00000193403; ENSP00000193403; ENSG00000072110. [P12814-1]; .
EnsemblENST00000394419; ENSP00000377941; ENSG00000072110. [P12814-3]; .
EnsemblENST00000438964; ENSP00000414272; ENSG00000072110. [P12814-2]; .
EnsemblENST00000538545; ENSP00000439828; ENSG00000072110. [P12814-4]; .
GeneID87; -; .
KEGGhsa:87; -; .
UCSCuc001xkl.4; human. [P12814-1]; .
CTD87; -; .
DisGeNET87; -; .
GeneCardsACTN1; -; .
HGNCHGNC:163; ACTN1; .
HPACAB004303; -; .
HPAHPA006035; -; .
MalaCardsACTN1; -; .
MIM102575; gene; .
MIM615193; phenotype; .
neXtProtNX_P12814; -; .
OpenTargetsENSG00000072110; -; .
Orphanet140957; Autosomal dominant macrothrombocytopenia; .
PharmGKBPA24; -; .
eggNOGKOG0035; Eukaryota; .
eggNOGCOG5069; LUCA; .
GeneTreeENSGT00760000118813; -; .
HOGENOMHOG000263418; -; .
HOVERGENHBG050453; -; .
InParanoidP12814; -; .
KOK05699; -; .
OMANDMTRKW; -; .
OrthoDBEOG091G020R; -; .
PhylomeDBP12814; -; .
TreeFamTF352676; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
ReactomeR-HSA-3000170; Syndecan interactions; .
ReactomeR-HSA-373753; Nephrin interactions; .
ReactomeR-HSA-446388; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components; .
SIGNORP12814; -; .
ChiTaRSACTN1; human; .
EvolutionaryTraceP12814; -; .
GeneWikiActinin; _alpha_1; -; .
GenomeRNAi87; -; .
PROPR:P12814; -; .
ProteomesUP000005640; Chromosome 14; .
BgeeENSG00000072110; -; .
CleanExHS_ACTN1; -; .
ExpressionAtlasP12814; baseline and differential; .
GenevisibleP12814; HS; .
GOGO:0005903; C:brush border; IEA:Ensembl; .
GOGO:0042995; C:cell projection; IDA:UniProtKB; .
GOGO:0005911; C:cell-cell junction; IDA:UniProtKB; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0005916; C:fascia adherens; IEA:Ensembl; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0005622; C:intracellular; IDA:UniProtKB; .
GOGO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0031143; C:pseudopodium; TAS:UniProtKB; .
GOGO:0001726; C:ruffle; IDA:UniProtKB; .
GOGO:0001725; C:stress fiber; IDA:UniProtKB; .
GOGO:0030018; C:Z disc; IEA:UniProtKB-SubCell; .
GOGO:0051015; F:actin filament binding; IDA:UniProtKB; .
GOGO:0005509; F:calcium ion binding; IEA:InterPro; .
GOGO:0003725; F:double-stranded RNA binding; IDA:MGI; .
GOGO:0005178; F:integrin binding; IDA:UniProtKB; .
GOGO:0044325; F:ion channel binding; IPI:UniProtKB; .
GOGO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IDA:UniProtKB; .
GOGO:0017166; F:vinculin binding; IDA:UniProtKB; .
GOGO:0051764; P:actin crosslink formation; IEA:InterPro; .
GOGO:0051017; P:actin filament bundle assembly; IEA:Ensembl; .
GOGO:0051639; P:actin filament network formation; IMP:UniProtKB; .
GOGO:0007015; P:actin filament organization; IMP:UniProtKB; .
GOGO:0048041; P:focal adhesion assembly; IMP:UniProtKB; .
GOGO:0051271; P:negative regulation of cellular component movement; IMP:UniProtKB; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0030220; P:platelet formation; IMP:UniProtKB; .
GOGO:0036344; P:platelet morphogenesis; IMP:UniProtKB; .
GOGO:0042981; P:regulation of apoptotic process; NAS:UniProtKB; .
CDDcd00014; CH; 2; .
CDDcd00051; EFh; 1; .
Gene3D1.10.238.10; -; 2; .
Gene3D1.10.418.10; -; 2; .
InterProIPR001589; Actinin_actin-bd_CS; .
InterProIPR026921; Alpha-actinin_1; .
InterProIPR001715; CH-domain; .
InterProIPR011992; EF-hand-dom_pair; .
InterProIPR014837; EF-hand_Ca_insen; .
InterProIPR018247; EF_Hand_1_Ca_BS; .
InterProIPR002048; EF_hand_dom; .
InterProIPR018159; Spectrin/alpha-actinin; .
InterProIPR002017; Spectrin_repeat; .
PANTHERPTHR11915:SF399; PTHR11915:SF399; 1; .
PfamPF00307; CH; 2; .
PfamPF08726; EFhand_Ca_insen; 1; .
PfamPF00435; Spectrin; 4; .
SMARTSM00033; CH; 2; .
SMARTSM00054; EFh; 2; .
SMARTSM00150; SPEC; 3; .
SUPFAMSSF47473; SSF47473; 1; .
SUPFAMSSF47576; SSF47576; 1; .
PROSITEPS00019; ACTININ_1; 1; .
PROSITEPS00020; ACTININ_2; 1; .
PROSITEPS50021; CH; 2; .
PROSITEPS00018; EF_HAND_1; 1; .
PROSITEPS50222; EF_HAND_2; 2; .



USC-OGP 2-DE database image


Gateways to other related servers


Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

[Home]